Sildenafil 50mg VI[DK] ​Japanese Herbal Male Enhancement​

Sildenafil 50mg Tablets “DK”​​

Manufacturer: Daiko Pharmaceutical Co.

Active Ingredient: Sildenafil Citrate (50mg)

Category: Oral Prescription Drug

​Indications​

▶️ Treatment of ​Erectile Dysfunction (ED)​​

​Pharmacology​

Sildenafil, originally developed for cardiovascular research, is a selective ​PDE5 inhibitor​ that enhances nitric oxide-mediated vasodilation in the penile corpus cavernosum, facilitating erections upon sexual stimulation.

​Critical Safety Information​

❗️ ​Black Box Warnings​

• ⛔ ​Contraindicated with nitrates​ (risk of fatal hypotension)
• ⛔ ​Avoid concurrent use with guanylate cyclase stimulators​
• ⚠️ Potential ​QT prolongation​ in predisposed patients

📋 ​Absolute Contraindications​

• Hypersensitivity to sildenafil
• Retinitis pigmentosa
• Severe hepatic impairment (Child-Pugh C)
• Uncontrolled hypertension (>170/100mmHg)
• Recent MI/stroke (<6 months)
• Concomitant use of Class III antiarrhythmics (e.g. amiodarone)

⚠️ ​Adverse Reactions (Incidence >1%)​​

* ​PRIAPISM ALERT: >4-hour erection requires emergency intervention

🧪 ​Laboratory Abnormalities​

• ↑ ALT/AST (5.8%)
• ↑ γ-GTP (4.2%)
• ↓ Hemoglobin (3.1%)

💊 ​Dosage & Administration​

1. ​Standard Dose: 25-50mg orally 1 hour before sexual activity
   • Maximum frequency: Once daily
   • Administration: With 240ml water on empty stomach
2. ​Special Populations:
   • ​Elderly (>65yo)​: Start with 25mg
   • ​Hepatic/Renal impairment (CrCl<30ml/min)​: 25mg initial dose

🧾 ​Product Specifications​

• ​Packaging: 10 tablets/blister
• ​Storage: Below 25°C in original container